SYNTHROID®levothyroxine sodium tablets, USP

Synthroid is also used in patients who need surgery and radioiodine therapy to manage a type of thyroid cancer called well-differentiated thyroid cancer. Synthroid is a prescription medicine used to treat hypothyroidism (low thyroid hormone). Levothyroxine is given when your thyroid does not produce enough of this hormone on its own.

Oral anticoagulants

Eltroxin is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Unithroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Levoxyl treats hypothyroidism (low thyroid hormone) and treats or prevents goiter. Tirosint is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Your child’s dose needs may change if the child gains or loses weight. Seizures have been reported rarely with the institution of levothyroxine therapy.

Their finding that sesamol supplementation alleviates cognitive dysfunction could lead to new treatments for Alzheimer’s disease. G. Archibald and coauthors at Fluorochem (Azusa, CA) and the US Naval Research Laboratory (Washington, DC). Because of its low melting point and high thermal stability as a liquid, it was proposed as a replacement for TNT2, but its high vapor pressure eliminated it as a melt-castable TNT substitute. Dextrothyroxine is the mirror form of levothyroxine with the opposite, non-natural chirality.

• Concomitant administration of levothyroxine and sympathomimetic agents to patients with coronary artery disease may precipitate coronary insufficiency.
• Thyroid hormones cross the placental barrier to some extent as evidenced by levels in cord blood of athyreotic fetuses being approximately one-third maternal levels.
• SYNTHROID is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.
• The recommended daily dosage of SYNTHROID in pregnant patients is described in Table 3.
• Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy.
• Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss.

TO INDICATE A PRESCRIPTION IS DAW-1

Because T4 is highly protein bound, very little drug will be removed by dialysis. Levothyroxine is contraindicated in patients with untreated subclinical (suppressed serum TSH level with normal T3 and T4 levels) or overt thyrotoxicosis of any etiology and in patients with acute myocardial infarction. Levothyroxine is contraindicated in patients with uncorrected adrenal insufficiency since thyroid hormones may precipitate an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids (see PRECAUTIONS).

Before taking this medicine

• In the treatment of benign nodules and nontoxic multinodular goiter, TSH is generally suppressed to a higher target (e.g., 0.1 to either 0.5 or 1.0 mU/L) than that used for the treatment of thyroid cancer.
• TSH lower limit of quantification was 0.2 mIU/L and upper limit of normal was 5.6 mIU/L, as indicated by the shaded area.
• Many other medicines can be affected by your thyroid hormone levels.
• Patients who are not treated should be monitored yearly for changes in clinical status and thyroid laboratory parameters.

Studies to evaluate mutagenic potential and animal fertility have not been performed. If cardiac symptoms develop or worsen, reduce the SYNTHROID dose or withhold for one week and restart at a lower dose. The peak therapeutic effect of a given dose of SYNTHROID may not be attained for 4 to 6 weeks. Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see DRUG INTERACTIONS. Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. This may be a life-threatening emergency, therefore, symptomatic and supportive therapy should be instituted immediately. If not contraindicated (e.g., by seizures, coma, or loss of the gag reflex), the stomach should be emptied by emesis or gastric lavage to decrease gastrointestinal absorption.

Check with your physician for additional information about side effects. Get medical help right away, if you have any of the symptoms listed above. 34-week prescription audit of 441 pharmacies (average 41 prescriptions per state) totaling 1908 new and renewed SYNTHROID prescriptions between August 1, 2020 and March 23, 2021. In addition to testing TSH, sometimes it may synthroid calories be important to run other labs such as a free T4, in addition to the TSH, to ensure you have accurate dosing in the medication. It occurs more in the elderly and is much more common in women than men. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Synthroid only for the indication prescribed.

If, after 30 days, the serum TSH is elevated above 20 mU/L, the diagnosis of permanent hypothyroidism is confirmed, and full replacement therapy should be resumed. However, if the serum TSH has not risen to greater than 20 mU/L, levothyroxine treatment should be discontinued for another 30-day trial period followed by repeat serum T4 and TSH testing. Although thyroid hormones are excreted only minimally in human milk, caution should be exercised when SYNTHROID is administered to a nursing woman. However, adequate replacement doses of levothyroxine are generally needed to maintain normal lactation.

• This document does not contain all possible side effects and others may occur.
• TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback.
• TSH, in turn, is the physiologic stimulus for the synthesis and secretion of thyroid hormones, L-thyroxine (T4) and L-triiodothyronine (T3), by the thyroid gland.
• Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products.
• Closely monitor infants during the first 2 weeks of SYNTHROID therapy for cardiac overload and arrhythmias.

Decreases in TBG concentrations are observed in nephrosis, severe hypoproteinemia, severe liver disease, acromegaly, and after androgen or corticosteroid therapy (see also Table 2). Infants with congenital hypothyroidism appear to be at increased risk for other congenital anomalies, with cardiovascular anomalies (pulmonary stenosis, atrial septal defect, and ventricular septal defect) being the most common association. The mechanisms by which thyroid hormones exert their physiologic actions are not completely understood, but it is thought that their principal effects are exerted through control of DNA transcription and protein synthesis.

Nephrosis, severe hypoproteinemia, severe liver disease, acromegaly, androgens, and corticosteroids decrease TBG concentration. Familial hyper- or hypo-thyroxine binding globulinemias have been described, with the incidence of TBG deficiency approximating 1 in 9000. Concurrent use of tyrosine-kinase inhibitors such as imatinib may cause hypothyroidism. Monitor serum free-T4 levels and maintain in the upper half of the normal range in these patients. Biotin supplementation may interfere with immunoassays for TSH, T4, and T3, resulting in erroneous thyroid hormone test results. Stop biotin and biotin-containing supplements for at least 2 days before assessing TSH and/or T4 levels see DRUG INTERACTIONS.